With regards to Renal and Urology News, Csaba P. Kovesdy, MD describes chronic kidney disease (CKD) as a slow, progressive loss of renal function and since about 90% of plasma phosphates are filtered in the glomerulus and 80%-97% of the filtered load is reabsorbed (mostly in the proximal tubule), gave the doc reason to believe that phosphorus may be a possible culprit. As mentioned in the article, the main regulators of proximal tubular reabsorption are the plasma phosphorus level and various hormones with phosphaturic properties, the main ones being parathyroid hormone (PTH) 2 and fibroblast growth factor 23 (FGF-23).
Frank hyperphosphatemia is a relatively rare occurrence in CKD, but higher levels of plasma phosphorus (even within the range regarded as “normal”) is associated with higher mortality and worsened progression of CKD. Lowering plasma phosphorus levels in CKD can be beneficial in treating SHPT, and could become an additional therapy to lower mortality and to alleviate progressive loss of kidney function.
http://www.renalandurologynews.com/how-phosphorus-affects-ckd-patients/article/58147/#
Hi Melissa
ReplyDeleteVery cool blogspot. It sounds to me that too much phosphorus may be worse than not enough. It seems there is an extremely fine line there.
Nanette
I agree nanette! It's so easy to just tell someone: "everything in moderation" but what happens when they are not sure of what that means? I think the hardest part is knowing how to do just that. Actions speak louder than words so to speak, so if we can give people some examples of foods that have too much or too little amounts of the vitamins we are researching in this course, then I think it creates a more descriptive visual and may help them to have a more hands-on approach to their nutrition.
ReplyDelete